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HomeProduct name list4-Cyclohexylphenol

4-Cyclohexylphenol

  • CAS NO.:1131-60-8
  • Empirical Formula: C12H16O
  • Molecular Weight: 176.25
  • MDL number: MFCD00035699
  • EINECS: 214-465-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 21:47:27
4-Cyclohexylphenol Structural

What is 4-Cyclohexylphenol?

The Uses of 4-Cyclohexylphenol

4-Cyclohexylphenol is a derivative of Cyclohexylphenol (CHP), which is widely used in the preparation of dyes, resins, and biocides[2]. 4-Cyclohexylphenol labelled with 35s can be used for metabolic studies[3].

Synthesis

4-Cyclohexylphenol is obtained by hydroalkylation of phenol using phenol as a raw material in the presence of a palladium catalyst and a molten salt (NaCl-AlCl3)[1]. The specific synthesis steps are as follows:
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.

References

[1] T. KAMIYAMA; M. I; S Enomoto. Hydroalkylation of phenol to cyclohexylphenol in the presence of Pd-Al2O3 and NaCl-AlCl3 under hydrogen pressure.[J]. Chemical & pharmaceutical bulletin, 1986. DOI:10.1248/CPB.34.450.
[2] S. GUTIéRREZ-RUBIO . Synthesis of cyclohexylphenol via phenol hydroalkylation using Co2P/zeolite catalysts[J]. Catalysis Today, 2022. DOI:10.1016/j.cattod.2021.11.039.
[3] D.J. HEARSE; Gillian M P; A H Olavesen. The preparation and characterization of a series of 35S-labelled aryl sulphate esters for metabolic studies[J]. Biochemical pharmacology, 1969. DOI:10.1016/0006-2952(69)90022-7.

Properties of 4-Cyclohexylphenol

Melting point: 130-135°C
Boiling point: 213-215°C
Density  0.9452 (rough estimate)
vapor pressure  0.823-3.6Pa at 25℃
refractive index  1.5415 (estimate)
storage temp.  Inert atmosphere,Room Temperature
form  Solid:flakes
pka 10.15±0.13(Predicted)
color  White to Light yellow to Light orange
Water Solubility  66.66mg/L(25 ºC)
Dielectric constant 4.0(54℃)
CAS DataBase Reference 1131-60-8(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 4-cyclohexyl-(1131-60-8)
EPA Substance Registry System Phenol, 4-cyclohexyl- (1131-60-8)

Safety information for 4-Cyclohexylphenol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Cyclohexylphenol

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