4-Cyclohexylphenol
- CAS NO.:1131-60-8
- Empirical Formula: C12H16O
- Molecular Weight: 176.25
- MDL number: MFCD00035699
- EINECS: 214-465-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 4-Cyclohexylphenol?
The Uses of 4-Cyclohexylphenol
4-Cyclohexylphenol is a derivative of Cyclohexylphenol (CHP), which is widely used in the preparation of dyes, resins, and biocides[2]. 4-Cyclohexylphenol labelled with 35s can be used for metabolic studies[3].
Synthesis
4-Cyclohexylphenol is obtained by hydroalkylation of phenol using phenol as a raw material in the presence of a palladium catalyst and a molten salt (NaCl-AlCl3)[1]. The specific synthesis steps are as follows:
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.
References
[1] T. KAMIYAMA; M. I; S Enomoto. Hydroalkylation of phenol to cyclohexylphenol in the presence of Pd-Al2O3 and NaCl-AlCl3 under hydrogen pressure.[J]. Chemical & pharmaceutical bulletin, 1986. DOI:10.1248/CPB.34.450.
[2] S. GUTIéRREZ-RUBIO . Synthesis of cyclohexylphenol via phenol hydroalkylation using Co2P/zeolite catalysts[J]. Catalysis Today, 2022. DOI:10.1016/j.cattod.2021.11.039.
[3] D.J. HEARSE; Gillian M P; A H Olavesen. The preparation and characterization of a series of 35S-labelled aryl sulphate esters for metabolic studies[J]. Biochemical pharmacology, 1969. DOI:10.1016/0006-2952(69)90022-7.
Properties of 4-Cyclohexylphenol
Melting point: | 130-135°C |
Boiling point: | 213-215°C |
Density | 0.9452 (rough estimate) |
vapor pressure | 0.823-3.6Pa at 25℃ |
refractive index | 1.5415 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
form | Solid:flakes |
pka | 10.15±0.13(Predicted) |
color | White to Light yellow to Light orange |
Water Solubility | 66.66mg/L(25 ºC) |
Dielectric constant | 4.0(54℃) |
CAS DataBase Reference | 1131-60-8(CAS DataBase Reference) |
NIST Chemistry Reference | Phenol, 4-cyclohexyl-(1131-60-8) |
EPA Substance Registry System | Phenol, 4-cyclohexyl- (1131-60-8) |
Safety information for 4-Cyclohexylphenol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Cyclohexylphenol
New Products
Tubulysin B Tubulysin E Tubulysin H Tubulysin C 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2,2-Difluoropropanol tetrahydro-4-methyl-2H-pyran Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
4-Cyclohexylphenol CAS 1131-60-8View Details
1131-60-8 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8