4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
- CAS NO.:7709-58-2
- Empirical Formula: C4H5Cl2NS
- Molecular Weight: 170.06
- MDL number: MFCD02094738
- EINECS: 672-064-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-13 17:03:25
What is 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE?
Chemical properties
White crystalline
The Uses of 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
4-(Chloromethyl)thiazole hydrochloride and its derivatives can be used to prepare 4-thiazole carboxylic acid. It has been shown that in the study of synthesis of conformationally restricted RGD-containing integrin ligands by efficient solid-phase intramolecular thioalkylation, the reaction of S-nucleophiles with the newly generated N-terminal 4-chloromethyl thiazoles afforded the desired cyclic RGD product 5 with high purity and good overall yield[1].
References
[1] ADEL NEFZI Jason E F. N-terminus 4-chloromethyl thiazole peptide as a macrocyclization tool in the synthesis of cyclic peptides: application to the synthesis of conformationally constrained RGD-containing integrin ligands[J]. Tetrahedron Letters, 2011. DOI:10.1016/j.tetlet.2010.12.043.
Properties of 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
Melting point: | 166-167 °C (sublm) |
storage temp. | Inert atmosphere,Room Temperature |
form | powder to crystal |
color | White to Light yellow |
CAS DataBase Reference | 7709-58-2(CAS DataBase Reference) |
Safety information for 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
InChIKey | NVTBASMQHFMANH-UHFFFAOYSA-N |
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ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
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