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HomeProduct name list4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

  • CAS NO.:7709-58-2
  • Empirical Formula: C4H5Cl2NS
  • Molecular Weight: 170.06
  • MDL number: MFCD02094738
  • EINECS: 672-064-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-13 17:03:25
4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE Structural

What is 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE?

Chemical properties

White crystalline

The Uses of 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

4-(Chloromethyl)thiazole hydrochloride and its derivatives can be used to prepare 4-thiazole carboxylic acid. It has been shown that in the study of synthesis of conformationally restricted RGD-containing integrin ligands by efficient solid-phase intramolecular thioalkylation, the reaction of S-nucleophiles with the newly generated N-terminal 4-chloromethyl thiazoles afforded the desired cyclic RGD product 5 with high purity and good overall yield[1].

References

[1] ADEL NEFZI  Jason E F. N-terminus 4-chloromethyl thiazole peptide as a macrocyclization tool in the synthesis of cyclic peptides: application to the synthesis of conformationally constrained RGD-containing integrin ligands[J]. Tetrahedron Letters, 2011. DOI:10.1016/j.tetlet.2010.12.043.

Properties of 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

Melting point: 166-167 °C (sublm)
storage temp.  Inert atmosphere,Room Temperature
form  powder to crystal
color  White to Light yellow
CAS DataBase Reference 7709-58-2(CAS DataBase Reference)

Safety information for 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H318:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

InChIKey NVTBASMQHFMANH-UHFFFAOYSA-N

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