4-CHLOROMERCURIBENZOIC ACID
Synonym(s):4-(Chloromercurio)benzoic acid;4-(Hydroxymercuri)benzoic acid;Dihydrofolate reductase;DYR;N/A
- CAS NO.:59-85-8
- Empirical Formula: C7H5ClHgO2
- Molecular Weight: 357.16
- MDL number: MFCD00002526
- EINECS: 200-442-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:19
What is 4-CHLOROMERCURIBENZOIC ACID?
Chemical properties
4-CHLOROMERCURIBENZOIC ACID is White Solid
The Uses of 4-CHLOROMERCURIBENZOIC ACID
4-CHLOROMERCURIBENZOIC ACID can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase).
The Uses of 4-CHLOROMERCURIBENZOIC ACID
A useful sulfhydryl reagent that reacts with Histidine 225C, a residue of the NhaA-Na/H Antiporter of Escherichia Coli
Definition
ChEBI: P-chloromercuribenzoic acid is a mercuribenzoic acid and a chlorine molecular entity. It is functionally related to a benzoic acid.
Safety Profile
Poison by intraperitoneal route. See also MERCURY COMPOUNDS. When heated to decomposition it emits very toxic fumes of Cland Hg.
Purification Methods
Its suspension in water is stirred with enough 1M NaOH to dissolve most of it: a small amount of insoluble matter is removed by centrifugation. The chloromercuribenzoic acid is then precipitated by adding 1M HCl and centrifuged off. The precipitation is repeated twice. Finally, the precipitate is washed three times with distilled water (by centrifugation), then dried in a thin layer under vacuum over P2O5 [Boyer J Am Chem Soc 76 4331 1954]. Chloromethylphosphonic acid dichloride [1983 -26 -2] M 167.4, b 50o/0.5mm, 52 -53(59)o/2mm, 63-65o/3mm, 78 -79o/10mm, 87 -88o/15mm, 102-103o/30mm, d 4 1.638, n D 1.4971. It is fractionally distilled using a short Claisen column and redistilled. The aniline salt has m 199-201o. The 3 1P NMR has a single peak at -38±2 ppm from 85% H3PO4. [Kinnear & Perren J Chem Soc 3437 1952, NMR: van Wazer et al. J Am Chem Soc 78 5715 1956, McConnell et al. J Org Chem 22 462 1957, Beilstein 1 III 2593, 1 IV 3068.]
Properties of 4-CHLOROMERCURIBENZOIC ACID
Melting point: | 287 °C (dec.)(lit.) |
storage temp. | -20°C Freezer |
solubility | Aqueous Base (Slightly, Heated), |
form | solid |
BRN | 3662892 |
CAS DataBase Reference | 59-85-8(CAS DataBase Reference) |
EPA Substance Registry System | Mercurate(1-), (4-carboxylatophenyl)chloro-, hydrogen (59-85-8) |
Safety information for 4-CHLOROMERCURIBENZOIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-CHLOROMERCURIBENZOIC ACID
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