4-Chloro-2,3-dimethylpyridine 1-oxide

CAS NO.：59886-90-7
Empirical Formula: C7H8ClNO
Molecular Weight: 157.6
MDL number: MFCD06411125
EINECS: 611-910-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-31 16:18:28

What is 4-Chloro-2,3-dimethylpyridine 1-oxide?

Chemical properties

Pale Yellow Solid

The Uses of 4-Chloro-2,3-dimethylpyridine 1-oxide

An intermediate in the synthesis of rabeprazole (R070500).

Synthesis

83.0 g (0.49 mol) of 4-nitro-2,3-dimethylpyridine N-oxide and 90 g (1.54 mol) of NaCl were admixed with 1350 ml of CH3CN, 180 ml of aq. HCl (36%) and 16.6 g of benzyltributylammonium chloride, and the resulting suspension was boiled under reflux with stirring for 12 h. The resulting reaction mixture was adjusted to PH=9 using 350 ml of 20% NaOH, wherefor the existing precipitate largely dissolved. The organic phase was separated off, water was added to the aqueous phase until the precipitate had completely dissolved, and it was subsequently extracted using dichloromethane. The organic phases were combined and the solvent was removed under reduced pressure. 76.6 g (98.5%) of 4-Chloro-2,3-dimethylpyridine 1-oxide were obtained.

Properties of 4-Chloro-2,3-dimethylpyridine 1-oxide

Melting point:	103-105°C
Boiling point:	338.5°C
Density	1.19
vapor pressure	0.346Pa at 25℃
Flash point:	158.5°C
storage temp.	Room temperature.
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	1.28±0.10(Predicted)
color	Pale Yellow to Light Beige
CAS DataBase Reference	59886-90-7(CAS DataBase Reference)

Safety information for 4-Chloro-2,3-dimethylpyridine 1-oxide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up.