4-CHLORO-2-PHENYLQUINAZOLINE

Synonym(s):AM-ex-OL;NSC 400965

CAS NO.：6484-25-9
Empirical Formula: C14H9ClN2
Molecular Weight: 240.69
MDL number: MFCD00006713
EINECS: 229-346-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 4-CHLORO-2-PHENYLQUINAZOLINE?

Chemical properties

slightly yellow to yellow crystalline powder

The Uses of 4-CHLORO-2-PHENYLQUINAZOLINE

4-Chloro-2-phenylquinazoline can be involved in the synthesis of biologically active molecules including: Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity.

The Uses of 4-CHLORO-2-PHENYLQUINAZOLINE

Reactant involved in the synthesis of biologically active molecules including:

Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity
Quinazoline-containing piperazinylpyrimidine derivatives with antitumor activity
Quinazoline substituted cyclopentane as HCV NS3/4A protease inhibitors
Quinazolines with antibacterial and antitumor activity
Aurora inhibitor MK-0457

Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution

What are the applications of Application

4-Chloro-2-phenylquinazoline is a reactant involved in Suzuki-Miyaura cross-coupling

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1299, 1946 DOI: 10.1021/ja01211a055

Properties of 4-CHLORO-2-PHENYLQUINAZOLINE

Melting point:	124-126 °C(lit.)
Boiling point:	383.11°C (rough estimate)
Density	1.285
refractive index	1.5749 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	0.67±0.30(Predicted)
form	Crystalline Powder
color	Slightly yellow to yellow
CAS DataBase Reference	6484-25-9(CAS DataBase Reference)

Safety information for 4-CHLORO-2-PHENYLQUINAZOLINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.