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HomeProduct name list4-Chloro-2-methylphenol

4-Chloro-2-methylphenol

Synonym(s):4-Chloro-o-cresol

  • CAS NO.:1570-64-5
  • Empirical Formula: C7H7ClO
  • Molecular Weight: 142.58
  • MDL number: MFCD00002321
  • EINECS: 216-381-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-12 15:32:57
4-Chloro-2-methylphenol Structural

What is 4-Chloro-2-methylphenol?

Chemical properties

Off-white to slightly brownish crystalline solid

The Uses of 4-Chloro-2-methylphenol

4-Chloro-2-methylphenol is a transformation/degredation product of herbicides found in the environment through landfills and runoff.

Definition

ChEBI: 4-chloro-2-methylphenol is a member of the class of phenols that is o-cresol in which the hydrogen para to the hydroxy group is replaced by a chlorine. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to an o-cresol.

What are the applications of Application

4-Chloro-2-methylphenol is an important pharmaceutical intermediate ingredient used in the manufacture of herbicides (Mecoprop, MCPA, and MCPB), as an additive tracer for resist plasma etching. It is used as a closed system intermediate in the production of phenoxy herbicides. It is also used as a disinfectant or bactericide.

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 5215, 1989 DOI: 10.1016/S0040-4039(01)93745-1

General Description

Dark red flakes with waxy texture. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chloro-2-methylphenol can react vigorously with concentrated sodium hydroxide solutions. Also reacts with other bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys [NTP, 1992)]. A large quantity left in contact with concentrated sodium hydroxide solution for 3 days reacted violently, attaining red heat and evolving fumes that ignited explosively. The heat of reaction dissipated poorly because of the high viscosity of the mixture [Quart. Safety Summ., 1957, 28, 39].

Fire Hazard

4-Chloro-2-methylphenol is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Purify the phenol by crystallisation from pet ether (m 51o) and by zone melting. [Beilstein 6 H 359, 6 I 174, 6 II 332, 6 III 1264, 6 IV 1987.]

Properties of 4-Chloro-2-methylphenol

Melting point: 43-46 °C(lit.)
alpha  22 º (c=8,6N HCl)
Boiling point: 220-225 °C(lit.)
Density  1.20
vapor pressure  26.66Pa at 19.85℃
refractive index  1.5449 (estimate)
Flash point: >230 °F
storage temp.  Inert atmosphere,Room Temperature
form  neat
pka 9.87±0.18(Predicted)
color  white to brown
Water Solubility  <0.1 g/100 mL at 15 ºC
BRN  1906684
CAS DataBase Reference 1570-64-5(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 4-chloro-2-methyl-(1570-64-5)
EPA Substance Registry System 4-Chloro-2-methylphenol (1570-64-5)

Safety information for 4-Chloro-2-methylphenol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H314:Skin corrosion/irritation
H331:Acute toxicity,inhalation
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Chloro-2-methylphenol

InChIKey RHPUJHQBPORFGV-UHFFFAOYSA-N

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