4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester

Synonym(s):1-Boc-4-bromomethylpiperidine

CAS NO.：158407-04-6
Empirical Formula: C11H20BrNO2
Molecular Weight: 278.19
MDL number: MFCD04115538
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Structural

What is 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester?

The Uses of 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester

4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process and chemical production process.

Synthesis

Synthesis_158407-04-6
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester. 4-N-Boc-piperidine-methanol (200 mg, 0.93 mmol) was dissolved in diethyl ether (9 mL) and carbon tetrabromide (370 mg, 1.1 mmol) and PPh3 (292 mg, 1.1 mmol) were added at rt. The reaction was allowed to stir for 18 h at rt and filtered over a pad of celite. The filtrate was concentrated and purified by flash chromatography (hexane/EtOAc, 1:0 ?ú 4:1) to give the title compound. Yield 55 mg. 1 (400 MHz, DMSO-d6) |? ppm 4.02-3.98 (m, 2 H), 3.47 (d, 2 H), 2.78-2.65 (m, 2 H), 1.89-1.74 (m, 3 H), 1.45 (s, 9 H), 1.12-0.98 (m, 2 H).

Properties of 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester

Boiling point:	318.3±15.0 °C(Predicted)
Density	1.270±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-1.91±0.40(Predicted)

Safety information for 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.