4-BROMO-A23187
Synonym(s):4-Bromo-A23187;4-Bromo-calcimycin
- CAS NO.：76455-48-6
- Empirical Formula: C29H36BrN3O6
- Molecular Weight: 602.52
- MDL number: MFCD00077667
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 4-BROMO-A23187?
Chemical properties
Yellow powder
The Uses of 4-BROMO-A23187
4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+.
The Uses of 4-BROMO-A23187
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
Biochem/physiol Actions
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
Properties of 4-BROMO-A23187
| Boiling point: | 735.4±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethanol: 20 mg/mL |
| pka | 15.14±0.50(Predicted) |
| form | powder |
| color | yellow |
Safety information for 4-BROMO-A23187
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-BROMO-A23187
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