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HomeProduct name list4-BROMO-A23187

4-BROMO-A23187

Synonym(s):4-Bromo-A23187;4-Bromo-calcimycin

4-BROMO-A23187 Structural

What is 4-BROMO-A23187?

Chemical properties

Yellow powder

The Uses of 4-BROMO-A23187

4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+.

The Uses of 4-BROMO-A23187

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.

Biochem/physiol Actions

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

Properties of 4-BROMO-A23187

Boiling point: 735.4±60.0 °C(Predicted)
Density  1.43±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  ethanol: 20 mg/mL
pka 15.14±0.50(Predicted)
form  powder
color  yellow

Safety information for 4-BROMO-A23187

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-BROMO-A23187

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