4-Bromo-4'-fluorobiphenyl

CAS NO.：398-21-0
Empirical Formula: C12H8BrF
Molecular Weight: 251.09
MDL number: MFCD00017954
EINECS: 206-909-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-18 20:10:17

What is 4-Bromo-4'-fluorobiphenyl?

Chemical properties

White powder, monoclinic, P21/c, a = 9.78(2), b = 13.33(2), c = 17.69(3) A, fl = 116.3(5) °, U = 2068.13(15) A3, Z = 8, Dx = 1.60 Mg m-3, Mo Kct radiation, 2 = 0-71069 A, /~ = 38-42 mm-1, F(000) = 992, T = 293K. Intensity data were only observable to a resolution of 1-1 A. 392 reflections were measured from a single crystal. 4,4'-disubstituted biphenyls crystallize in spacegroup No. 14 with either Z = 8 or Z = 2 [Brock, Kuo & Levy (1978). Acta Cryst. B34, 981-985]. The 4F,4'F compound is of the latter type, the 4Br,4'Br is of the former. This study was undertaken to find out to which group (if either) the mixed 4Br,4'F compound belonged. It is in fact isostructural with 4,4'-dibromobiphenyl.

The Uses of 4-Bromo-4'-fluorobiphenyl

4-Bromo-4'-fluorobiphenyl is a reagent used in the preparation of 5-hydroxypyrimidine-4-carboxamide compounds for promoting erythropoietin (EPO) production.

Safety

4-Bromo-4'-fluorobiphenyl is flammable and its containers may explode when heated. Vapors may form explosive mixtures with air and travel to the source of ignition and flash back.

Properties of 4-Bromo-4'-fluorobiphenyl

Melting point:	92.5-97.5 °C(lit.)
storage temp.	Sealed in dry,Room Temperature
color	White to off-white
InChI	InChI=1S/C12H8BrF/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H
CAS DataBase Reference	398-21-0(CAS DataBase Reference)
NIST Chemistry Reference	4-Bromo-4'-fluorobiphenyl(398-21-0)

Safety information for 4-Bromo-4'-fluorobiphenyl

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.