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HomeProduct name list4-Bromo-2,6-difluorobenzaldehyde

4-Bromo-2,6-difluorobenzaldehyde

  • CAS NO.:537013-51-7
  • Empirical Formula: C7H3BrF2O
  • Molecular Weight: 221
  • MDL number: MFCD03094459
  • EINECS: 675-098-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-08-15 13:09:01
4-Bromo-2,6-difluorobenzaldehyde Structural

What is 4-Bromo-2,6-difluorobenzaldehyde?

The Uses of 4-Bromo-2,6-difluorobenzaldehyde

4-Bromo-2,6-difluorobenzaldehyde can be used as organic synthesis and pharmaceutical intermediates, mainly in laboratory research and development, chemical and pharmaceutical production processes.

Synthesis

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n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78°C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20°C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200 mg, 0.938 mmol) in dry THF at -78°C, continued stirring for a further 30 minutes at -78°C, followed by the addition of N-chlorosuccinamide (225 mg, 1.68 mmol) in dry THF at -78°C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded the product. Preparation of Intermediate 4-Bromo-2,6-difluoro-benzaldehyde (I-26a): Using analogous reaction condition and reagents as described in Example 20 for the preparation of 1-20a above, 1-bromo-3,5-difluoro-benzene (2 g, 2.10.36 mmol) in THF was reacted with DMF (1.43 g,19.68 mmol), n-butyl lithium (1.56 ml, 12.4 mmol) and diisopropyl amine (0.57 mL, 15.5 mmol) to afford crude product. Purification by column chromatography on silica gel (2% ethyl acetate in hexane) afforded 1.35 g of the product (61% yield). 1H NMR (CDCl3, 300 MHz): δ 11.5-11.0 (s, 1H), 7.4-7.2 (dd, 2H).

Properties of 4-Bromo-2,6-difluorobenzaldehyde

Melting point: 76-81 °C
Boiling point: 231.4±40.0℃ (760 Torr)
Density  1.758±0.06 g/cm3 (20 ºC 760 Torr)
Flash point: 93.7±27.3℃
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
form  powder to crystal
color  White to Light yellow to Light orange
Sensitive  Air Sensitive
InChI InChI=1S/C7H3BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-3H
CAS DataBase Reference 537013-51-7(CAS DataBase Reference)

Safety information for 4-Bromo-2,6-difluorobenzaldehyde

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for 4-Bromo-2,6-difluorobenzaldehyde

InChIKey CZGVAISJIQNQEJ-UHFFFAOYSA-N
SMILES C(=O)C1=C(F)C=C(Br)C=C1F

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