4-BIPHENYLSULFONYL CHLORIDE

Synonym(s):(4-Biphenylyl)sulfonyl chloride;p-Biphenylsulfonyl chloride;p-Phenylbenzenesulfonyl chloride;4-(Chlorosulfonyl)biphenyl;4-Phenylbenzenesulfonic acid chloride

CAS NO.：1623-93-4
Empirical Formula: C12H9ClO2S
Molecular Weight: 252.72
MDL number: MFCD00078658
EINECS: 216-609-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:19

What is 4-BIPHENYLSULFONYL CHLORIDE?

Chemical properties

White crystalline powder

The Uses of 4-BIPHENYLSULFONYL CHLORIDE

Reactant for:• ;Preparation of anilinopyrimidinesulfonamides as potential anticancer agents1• ;Synthesis of inhibitors of the hypoxia inducible factor pathway2• ;Preparation of hydroxy-sulfonyl-piperidinyl butyramides as HDAC inhibitors and potential antitumors3• ;Palladium-catalyzed desulfitative C-arylation4

The Uses of 4-BIPHENYLSULFONYL CHLORIDE

It is a reactant for preparation of anilinopyrimidinesulfonamides as potential anticancer agents, synthesis of inhibitors of the hypoxia inducible factor pathway. It participates in the preparation of hydroxy-sulfonyl-piperidinyl butyramides as HDAC inhibitors and potential antitumors and is also involved in palladium-catalyzed desulfitative C-arylation.

What are the applications of Application

Biphenyl-4-sulfonyl chloride is a potent HDAC inhibitor with catalytic applications

Properties of 4-BIPHENYLSULFONYL CHLORIDE

Melting point:	103-108 °C(lit.)
Boiling point:	200-205°C 6mm
Density	1.320±0.06 g/cm3(Predicted)
Flash point:	200-205°C/6mm
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO: 50 mg/mL (197.85 mM);;
form	Crystalline Powder
color	White
Water Solubility	Reacts with water.
Sensitive	Moisture Sensitive
BRN	2694373
CAS DataBase Reference	1623-93-4(CAS DataBase Reference)

Safety information for 4-BIPHENYLSULFONYL CHLORIDE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.