Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list4-Benzylpiperidine

4-Benzylpiperidine

Synonym(s):Phenyl(4-piperidyl)methane

  • CAS NO.:31252-42-3
  • Empirical Formula: C12H17N
  • Molecular Weight: 175.27
  • MDL number: MFCD00006006
  • EINECS: 250-535-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
4-Benzylpiperidine Structural

What is 4-Benzylpiperidine?

Chemical properties

clear colourless to yellow viscous liquid.

The Uses of 4-Benzylpiperidine

4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

What are the applications of Application

4-Benzylpiperidine is a reactant for the synthesis of antiproliferatives, GABA uptake inhibitors, and pyridines

Preparation

4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

What are the applications of Application

Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Synthesis Reference(s)

Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196

General Description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

Properties of 4-Benzylpiperidine

Melting point: 6-7 °C (lit.)
Boiling point: 279 °C (lit.)
Density  0.997 g/mL at 25 °C (lit.)
refractive index  n20/D 1.537(lit.)
Flash point: >230 °F
storage temp.  Store below +30°C.
form  Viscous Liquid
pka 10.58±0.10(Predicted)
color  Clear colorless to yellow
BRN  132339
CAS DataBase Reference 31252-42-3(CAS DataBase Reference)
EPA Substance Registry System Piperidine, 4-(phenylmethyl)- (31252-42-3)

Safety information for 4-Benzylpiperidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Benzylpiperidine

Related products of tetrahydrofuran

You may like

  • 31252-42-3 4-Benzylpiperidine 98%
    31252-42-3 4-Benzylpiperidine 98%
    31252-42-3
    View Details
  • Phenyl(4-piperidyl)methane, 99% CAS 31252-42-3
    Phenyl(4-piperidyl)methane, 99% CAS 31252-42-3
    31252-42-3
    View Details
  • 4-Benzylpiperidine CAS 31252-42-3
    4-Benzylpiperidine CAS 31252-42-3
    31252-42-3
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.