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HomeProduct name list4-Aminoindole

4-Aminoindole

Synonym(s):(Indol-4-yl)amine;4-Indolamine

  • CAS NO.:5192-23-4
  • Empirical Formula: C8H8N2
  • Molecular Weight: 132.16
  • MDL number: MFCD01076559
  • EINECS: 621-202-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:39
4-Aminoindole Structural

What is 4-Aminoindole?

Chemical properties

Greenish-grey to tan powder

The Uses of 4-Aminoindole

4-Aminoindole may be used to synthesize:

  • macrolactam tumour promoter indolactam V
  • tricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one
  • 4-azidoindole

The Uses of 4-Aminoindole

Reactant for preparation of:• ;Inhibitors of bacterial thymidylate synthase1• ;Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)2• ;Inhibitors of Gli1-mediated transcription in the Hedgehog pathway3• ;Protein kinase C θ (PKCθ) inhibitors4• ;Indolic non-peptidic HIV protease inhibitors5• ;Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists6• ;Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors7• ;11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibi

Definition

ChEBI: 4-Aminoindole is a member of indoles.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 5130, 1983 DOI: 10.1021/jo00173a071

General Description

4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay. 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.

Properties of 4-Aminoindole

Melting point: 106-109 °C (lit.)
Boiling point: 354.0±15.0 °C(Predicted)
Density  1.268±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
form  powder to crystal
pka 18.23±0.30(Predicted)
color  White to Gray to Brown
Water Solubility  Insoluble
Sensitive  Air Sensitive
BRN  114919
CAS DataBase Reference 5192-23-4(CAS DataBase Reference)

Safety information for 4-Aminoindole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Aminoindole

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