4-Amino-6-chlorobenzene-1,3-disulfonamide
Synonym(s):3-Chloroaniline-4,6-disulfonamide;4-Amino-6-chloro-1,3-benzenedisulfonamide;4-Amino-6-chlorobenzene-1,3-disulfonamide
- CAS NO.:121-30-2
- Empirical Formula: C6H8ClN3O4S2
- Molecular Weight: 285.73
- MDL number: MFCD00007933
- EINECS: 204-463-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:32
What is 4-Amino-6-chlorobenzene-1,3-disulfonamide ?
Description
4-Amino-6-chlorobenzene-1,3-disulfonamide is obtained by treating the chloride with ammonia in tert-butanol and concentrating the solution by evaporation; the yield is 80 %. Condensation with formic acid gives 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, an important diuretic.
Chemical properties
Light Brown Solid
The Uses of 4-Amino-6-chlorobenzene-1,3-disulfonamide
Diuretic.
The Uses of 4-Amino-6-chlorobenzene-1,3-disulfonamide
4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes.
What are the applications of Application
4-Amino-6-chloro-1,3-benzenedisulfonamide is an important target compound useful in long time detection of thiazide diuretics
Definition
ChEBI: Chloraminophenamide is a sulfonamide.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Properties of 4-Amino-6-chlorobenzene-1,3-disulfonamide
Melting point: | 257-261 °C(lit.) |
Boiling point: | 614.4±65.0 °C(Predicted) |
Density | 1.584 (estimate) |
refractive index | 1.6100 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Powder |
pka | 9.24±0.60(Predicted) |
color | White to off-white |
Merck | 14,2076 |
BRN | 1083877 |
CAS DataBase Reference | 121-30-2(CAS DataBase Reference) |
EPA Substance Registry System | 1,3-Benzenedisulfonamide, 4-amino-6-chloro- (121-30-2) |
Safety information for 4-Amino-6-chlorobenzene-1,3-disulfonamide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-Amino-6-chlorobenzene-1,3-disulfonamide
4-Amino-6-chlorobenzene-1,3-disulfonamide manufacturer
Molsyns Research
Ralington Pharma
Clickchem Research LLP
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