4-AMINO-2,6-DIBROMOPHENOL

CAS NO.：609-21-2
Empirical Formula: C6H5Br2NO
Molecular Weight: 266.92
MDL number: MFCD00007874
EINECS: 210-185-1
SAFETY DATA SHEET (SDS)
Update Date: 2022-11-25 16:07:05

What is 4-AMINO-2,6-DIBROMOPHENOL?

Chemical properties

beige to pale brown crystalline powder

Synthesis

The synthesis of 4-amino-2,6-dibromophenol is as follows:4-Nitro-2,6-dibromophenol (2.97g, 10mmol) was dissolved in ethanol (15ml) and water (3ml), and acetic acid (1ml) was added. Then heat and stir to raise the temperature to 80°C, and add iron powder (1.68g, 30mmol) in batches. After the addition is complete, the reaction solution is kept warm for 30 minutes, heating is stopped, filtered while hot, the filtrate is concentrated under reduced pressure, then ethyl acetate and water are added to the concentrated residue to extract, the organic phases are combined and dried, filtered, and the solvent is removed under reduced pressure. The residue was finally separated by column chromatography (ethyl acetate/petroleum ether=1/3) to obtain 4-amino-2,6-dibromophenol (2.52g, 94.4% yield).
synthesis of 4-AMINO-2,6-DIBROMOPHENOL

Properties of 4-AMINO-2,6-DIBROMOPHENOL

Melting point:	195-196 °C(lit.)
Boiling point:	295.6±40.0 °C(Predicted)
Density	2.0444 (rough estimate)
refractive index	1.6400 (estimate)
storage temp.	2-8°C(protect from light)
pka	7.17±0.23(Predicted)
BRN	2803732
CAS DataBase Reference	609-21-2(CAS DataBase Reference)
EPA Substance Registry System	Phenol, 4-amino-2,6-dibromo- (609-21-2)

Safety information for 4-AMINO-2,6-DIBROMOPHENOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.