4-Amino-2-nitrophenol

Chemical properties

DARK BROWN FINE CRYSTALLINE POWDER

Chemical properties

4-Amino-2-nitrophenol is a dark red crystalline or reddish-purple solid.

The Uses of 4-Amino-2-nitrophenol

4-Amino-2-nitrophenol has been used in dyeing human hair and animal fur. The typical concentration in the “semipermanent” hair dyes was estimated to be on the order of 0.1–1.0%.

The Uses of 4-Amino-2-nitrophenol

4-Amino-2-nitrophenol was used in determination of aminonitrophenols in hair dyes by differential pulse voltammetry and HPLC with electrochemical detection. It is commonly used as semipermanent (nonoxidative) hair colorant and toner in permanent (oxidative) hair dye products.

Definition

ChEBI: 4-Amino-2-nitrophenol is a member of 2-nitrophenols.

General Description

Dark red plates, needles or reddish-purple powder. Melting point 125-127°C.

Air & Water Reactions

Sensitive to oxidation upon prolonged exposure to air. Insoluble in water.

Reactivity Profile

4-Amino-2-nitrophenol may react with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .

Fire Hazard

Flash point data for 4-Amino-2-nitrophenol are not available. 4-Amino-2-nitrophenol is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Very poisonous by intraperitoneal route. Moderately toxic by ingestion. A severe eye heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

In dye formulation for furs and hair

Carcinogenicity

Under the conditions of the bioassay, the compound was carcinogenic in male rats inducing transitional cell carcinomas of the urinary bladder (controls 0/15, lowdose 0/46, high dose 11/39). The same tumor was also observed in three dosed female rats and may have been associated with the administration of the chemical. No evidence of carcinogenic activity was found in the mice.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. It is unknown if this nitro compound is explosive; some are flammable and explosive, and the contact with alkali increases thermal sensitivity of these materials.