4-AMINO-2-MERCAPTOPYRIMIDINE
Synonym(s):4-Amino-2-mercaptopyrimidine;4-Amino-2-thiopyrimidine
- CAS NO.：333-49-3
- Empirical Formula: C4H5N3S
- Molecular Weight: 127.17
- MDL number: MFCD00057341
- EINECS: 206-374-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-AMINO-2-MERCAPTOPYRIMIDINE?
Chemical properties
Beige toYellow Powder
The Uses of 4-AMINO-2-MERCAPTOPYRIMIDINE
2-Thiocytosine has been used to investigate the reactions involved in hole transfer (HT) in X-irradiated doped cytosine monohydrate.
The Uses of 4-AMINO-2-MERCAPTOPYRIMIDINE
This compound has been shown to inhibit iodothyronine 5’-deiodinase, the enzyme responsible for the 5’-deiodination of thyroxine in human liver cells.
General Description
2-Thiocytosine is a potential antileukemic and anticancer agent. 2-Thiocytosine in solid state has been investigated by (1)H-(14)N NMR-NQR double resonance (NQDR) spectroscopy and theoretically by the quantum theory of atoms in molecules (QTAIM)/density functional theory (DFT).
Purification Methods
It is recrystallised from hot H2O and dried at 100o to constant weight. [Brown J Appl Chem (London) 9 203 1959, Russell et al. J Am Chem Soc 71 2279 1949.] It is used in transcription and translation studies [Rachwitz & Scheit Eur J Biochem 72 191 1977].
Properties of 4-AMINO-2-MERCAPTOPYRIMIDINE
| Melting point: | 285-290 °C (dec.)(lit.) |
| Boiling point: | 232.1±43.0 °C(Predicted) |
| Density | 1.313 (estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Powder |
| pka | 7.91±0.10(Predicted) |
| color | Yellow |
| BRN | 112435 |
| CAS DataBase Reference | 333-49-3(CAS DataBase Reference) |
| EPA Substance Registry System | 2(1H)-Pyrimidinethione, 4-amino- (333-49-3) |
Safety information for 4-AMINO-2-MERCAPTOPYRIMIDINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-AMINO-2-MERCAPTOPYRIMIDINE
New Products
6-Bromo 2-Iodo Indole Ivermectin EP Impurity B Rimegepant Impurity 3 Fosfomycin EP impurity D Tubulysin I 2,2-diethoxyethanethioamide Tubulysin A Tubulysin H (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine 2-Ethoxy-4-nitrobenzoic acid (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 3-Morpholino-5,6-dihydropyridin-2(1H)-one 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione N-Boc-(S)-2-amino-3-benzyloxy-1-propanol 4-bromo-7H-pyrrolo[2,3-d]pyrimidine 5-bromo-3-iodopyridin-2-olRelated products of tetrahydrofuran
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