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HomeProduct name list4-Amidinophenylmethanesulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Synonym(s):p-Amidinophenylmethylsulfonylfluoride, HCl;p-APMSF;p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem;4-Amidinobenzylsulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Structural

What is 4-Amidinophenylmethanesulfonyl fluoride hydrochloride?

Description

p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

What are the applications of Application

p-APMSF, Hydrochloride is an irreversible and specific protease inhibitor

Biochem/physiol Actions

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

Properties of 4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Melting point: ~205 °C (dec.)
storage temp.  -20°C
solubility  H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
form  White solid
BRN  9083148
CAS DataBase Reference 74938-88-8(CAS DataBase Reference)

Safety information for 4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for 4-Amidinophenylmethanesulfonyl fluoride hydrochloride

InChIKey KHLLRHIUKOJXLL-UHFFFAOYSA-N

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