4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- CAS NO.:2093386-50-4
- Empirical Formula: C19H24N4O4
- Molecular Weight: 372.42
- MDL number: MFCD31729298
- Update Date: 2023-07-14 17:45:51
What is 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl?
Biological Activity
Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
Properties of 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Boiling point: | 648.2±55.0 °C(Predicted) |
Density | 1.342±0.06 g/cm3(Predicted) |
pka | 10.75±0.40(Predicted) |
Safety information for 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Computed Descriptors for 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Rimegepant Impurity 3 Ivermectin EP Impurity B Fosfomycin EP impurity D Tubulysin F (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin E Tubulysin B Tubulysin G 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 2-(4-Bromopyridin-2-yl)acetonitrile 3-Morpholino-5,6-dihydropyridin-2(1H)-one 2-Ethoxy-4-nitrobenzoic acid (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 5,5-dimethyloxepan-2-one 4-fluoro-1-methyl-pyrazoleRelated products of tetrahydrofuran
Thalidomide-NH-PEG2-C2-NH2 (TFA)
Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Thalidomide-O-amido-C2-NH2
E3 ligase Ligand-Linker Conjugates 15
Thalidomide-NH-C6-NH2 TFA
-alkylC5-amine
2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
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