4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
Synonym(s):DIDS;Disodium 4,4′-diisothiocyanatostilbene-2,2′-disulfonate
- CAS NO.：207233-90-7
- Empirical Formula: C16H13N2NaO7S4
- Molecular Weight: 496.52
- MDL number: MFCD00009638
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&?
The Uses of 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt hydrate has been used:
- as band3 protein inhibitor in rabbits(19)
- for the inhibition of bicarbonate transporters in brain slice tissue(20)
- as HCO3-/Cl- exchanger (anion exchanger) in embryos(21)
Biochem/physiol Actions
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is an anionic alkylating agent containing isothiocyanate residue. It is a negatively charged homobifunctional cross-linking reagent. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is a specific inhibitor of cellular anion permeability used in cell transport studies. The isothiocyanate groups react with primary amines at pH 9.0-10.0. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid alkylates lysine residues and inhibits apoptosis indirectly by targeting membrane based anion transporters.In addition, it also inhibits calcium transport in vesicles.
Properties of 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
| storage temp. | 2-8°C |
| solubility | 0.1 M potassium bicarbonate: soluble50mg/mL |
| form | powder |
| color | yellow |
| BRN | 8179433 |
Safety information for 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
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