4-(2-Aminoethyl)morpholine

Synonym(s):2-Morpholinoethylamine

CAS NO.：2038-03-1
Empirical Formula: C6H14N2O
Molecular Weight: 130.19
MDL number: MFCD00006182
EINECS: 218-011-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 10:25:48

What is 4-(2-Aminoethyl)morpholine?

Chemical properties

clear colorless to pale yellow liq. after melting

The Uses of 4-(2-Aminoethyl)morpholine

4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II).

The Uses of 4-(2-Aminoethyl)morpholine

4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:

Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.
Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.
Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.
It is also used as a precursor to synthesize a variety of antimicrobial agents.

Definition

ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008

Properties of 4-(2-Aminoethyl)morpholine

Melting point:	24 °C
Boiling point:	205 °C(lit.)
Density	0.992 g/mL at 25 °C(lit.)
refractive index	n20/D 1.476(lit.)
Flash point:	347 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Chloroform, Methanol
pka	pK1: 4.06(+2);pK2: 9.15(+1) (25°C)
form	Liquid After Melting
color	Clear colorless to pale yellow
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	104378
Stability:	Air Sensitive
CAS DataBase Reference	2038-03-1(CAS DataBase Reference)
NIST Chemistry Reference	4-Morpholineethanamine(2038-03-1)
EPA Substance Registry System	4-Morpholineethanamine (2038-03-1)

Safety information for 4-(2-Aminoethyl)morpholine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.