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HomeProduct name list4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Synonym(s):4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzene sulfonamide;4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide;5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

  • CAS NO.:16673-34-0
  • Empirical Formula: C16H17ClN2O4S
  • Molecular Weight: 368.84
  • MDL number: MFCD00193756
  • EINECS: 240-722-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Structural

What is 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide?

Description

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

Chemical properties

Light Yellow Solid

The Uses of 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

An impurity arising in the synthesis of Glyburide (G598350).

General Description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

storage

Store at +4°C

References

1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316

Properties of 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Melting point: 209-214 °C
Density  1.356±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 45 mg/ml).
form  neat
pka 10.14±0.10(Predicted)
form  Solid
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference 16673-34-0(CAS DataBase Reference)

Safety information for 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Computed Descriptors for 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Abamectin manufacturer

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Glyra Health Care Pvt Ltd

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product: 16673-34-0 5-Chloro-2-methoxy-N-[2-(4-sulfamoyl-phenyl)-ethyl]-benzamide 99%
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Medilux Laboratories Pvt Ltd

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product: 16673-34-0 5-Chloro-2-methoxy-N-[2-(4-sulfamoyl-phenyl)-ethyl]-benzamide 98%
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Sibram Pharmaceutical

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product: 16673-34-0 99%
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Clickchem Research LLP

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Phone:+91-8140031133
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product: Glyburide Related Compound A 90 % Above
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