4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Synonym(s):4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzene sulfonamide;4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide;5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
- CAS NO.:16673-34-0
- Empirical Formula: C16H17ClN2O4S
- Molecular Weight: 368.84
- MDL number: MFCD00193756
- EINECS: 240-722-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide?
Description
NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
Chemical properties
Light Yellow Solid
The Uses of 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
An impurity arising in the synthesis of Glyburide (G598350).
General Description
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.
storage
Store at +4°C
References
1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316
Properties of 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Melting point: | 209-214 °C |
Density | 1.356±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 45 mg/ml). |
form | neat |
pka | 10.14±0.10(Predicted) |
form | Solid |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 16673-34-0(CAS DataBase Reference) |
Safety information for 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Computed Descriptors for 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide manufacturer
Venkatasai Life Sciences
Elixir Pharma
Ralington Pharma
Glyra Health Care Pvt Ltd
Medilux Laboratories Pvt Ltd
Clickchem Research LLP
ELIXIR PHARMA
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