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HomeProduct name list3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine dihydrate

  • CAS NO.:300-39-0
  • Empirical Formula: C9H9I2NO3
  • Molecular Weight: 432.98
  • MDL number: MFCD00016542
  • EINECS: 206-092-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
3,5-Diiodo-L-tyrosine dihydrate Structural

What is 3,5-Diiodo-L-tyrosine dihydrate?

Description

Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.

Chemical properties

white to beige powder

The Uses of 3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.

The Uses of 3,5-Diiodo-L-tyrosine dihydrate

It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.

The Uses of 3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Definition

ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.

Synthesis

Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.

Synthesis_300-39-0

Purification Methods

It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

Properties of 3,5-Diiodo-L-tyrosine dihydrate

Melting point: 200 °C (dec.)(lit.)
Boiling point: 546.5°C (rough estimate)
alpha  -20.7 º (c=2.5, 0.1N NaOH/H2O)
Density  2.405±0.06 g/cm3(Predicted)
refractive index  1.2 ° (C=5, 1mol/L HCl)
storage temp.  2-8°C
solubility  Aqueous Acid (Slightly), DMSO (Slightly)
form  crystalline
pka 2.12(at 25℃)
color  white
Water Solubility  slightly soluble
Sensitive  Light Sensitive
CAS DataBase Reference 300-39-0(CAS DataBase Reference)
NIST Chemistry Reference 3,5-Diiodo-l-tyrosine(300-39-0)
EPA Substance Registry System L-Tyrosine, 3,5-diiodo- (300-39-0)

Safety information for 3,5-Diiodo-L-tyrosine dihydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 3,5-Diiodo-L-tyrosine dihydrate

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