3,5-Diiodo-L-tyrosine dihydrate
- CAS NO.:300-39-0
- Empirical Formula: C9H9I2NO3
- Molecular Weight: 432.98
- MDL number: MFCD00016542
- EINECS: 206-092-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is 3,5-Diiodo-L-tyrosine dihydrate?
Description
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Chemical properties
white to beige powder
The Uses of 3,5-Diiodo-L-tyrosine dihydrate
3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.
The Uses of 3,5-Diiodo-L-tyrosine dihydrate
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.
The Uses of 3,5-Diiodo-L-tyrosine dihydrate
3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Synthesis
Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.
Purification Methods
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]
Properties of 3,5-Diiodo-L-tyrosine dihydrate
Melting point: | 200 °C (dec.)(lit.) |
Boiling point: | 546.5°C (rough estimate) |
alpha | -20.7 º (c=2.5, 0.1N NaOH/H2O) |
Density | 2.405±0.06 g/cm3(Predicted) |
refractive index | 1.2 ° (C=5, 1mol/L HCl) |
storage temp. | 2-8°C |
solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
form | crystalline |
pka | 2.12(at 25℃) |
color | white |
Water Solubility | slightly soluble |
Sensitive | Light Sensitive |
CAS DataBase Reference | 300-39-0(CAS DataBase Reference) |
NIST Chemistry Reference | 3,5-Diiodo-l-tyrosine(300-39-0) |
EPA Substance Registry System | L-Tyrosine, 3,5-diiodo- (300-39-0) |
Safety information for 3,5-Diiodo-L-tyrosine dihydrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 3,5-Diiodo-L-tyrosine dihydrate
Abamectin manufacturer
Medilux Laboratories Pvt Ltd
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