3,5-Difluoropyridine
- CAS NO.：71902-33-5
- Empirical Formula: C5H3F2N
- Molecular Weight: 115.08
- MDL number: MFCD03412222
- EINECS: 624-636-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-08 17:45:00
What is 3,5-Difluoropyridine?
Chemical properties
Liquid
Preparation
Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8.
Properties of 3,5-Difluoropyridine
| Boiling point: | 92-93°C |
| Density | 1.256 g/mL at 25 °C |
| refractive index | 1.4437 |
| Flash point: | 9°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| pka | 0.39±0.20(Predicted) |
| color | Colorless to Almost colorless |
| BRN | 7914363 |
| CAS DataBase Reference | 71902-33-5(CAS DataBase Reference) |
Safety information for 3,5-Difluoropyridine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 3,5-Difluoropyridine
| InChIKey | WRXAZPPGFLETFR-UHFFFAOYSA-N |
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