3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL

Synonym(s):4-Methyl-2-imidazolidinethione

CAS NO.：2055-46-1
Empirical Formula: C4H8N2S
Molecular Weight: 116.18
MDL number: MFCD00060526
EINECS: 218-152-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL Structural

What is 3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL?

The Uses of 3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL

Tetrahydropyrimidine-2(1H)-thione is a reactant in the preparation of aryl substituted heterocycles.

Preparation

The preparation of 3,4,5,6-Tetrahydro-2- pyrimidinethiol is as follows:Carbon disulfide (0.2 mol) was added dropwise to a solution of 1,3-diamino propane 1 (0.2 mol) in H2O/EtOH (20 ml), and the temperature was remained constant at 0-5 oC. After the completion of addition, the reaction mixture was refluxed for 12h and then cooled to room temperature. The precipitate was collected by filtration and recrystallized from EtOH to give pure desired compound.

Properties of 3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL

Melting point:	210-212 °C (lit.)
Boiling point:	171.6±23.0 °C(Predicted)
Density	1.095 (estimate)
refractive index	1.5000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	14.98±0.20(Predicted)
form	solid
color	White to Off-White
CAS DataBase Reference	2055-46-1(CAS DataBase Reference)
EPA Substance Registry System	Propylenethiourea (2055-46-1)

Safety information for 3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.