3,4-Methylenedioxy-beta-nitrostyrene

Synonym(s):3,4-Methylenedioxy-β-nitrostyrene;Syk Inhibitor III - CAS 1485-00-3 - Calbiochem

CAS NO.：1485-00-3
Empirical Formula: C9H7NO4
Molecular Weight: 193.16
MDL number: MFCD00014575
EINECS: 622-830-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-18 17:01:59

3,4-Methylenedioxy-beta-nitrostyrene Structural

What is 3,4-Methylenedioxy-beta-nitrostyrene?

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical properties

yellow powder

The Uses of 3,4-Methylenedioxy-beta-nitrostyrene

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

What are the applications of Application

MNS is a selective inhibitor of Syk kinase activity

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

References

1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546

Properties of 3,4-Methylenedioxy-beta-nitrostyrene

Melting point:	159-163 °C
Boiling point:	329.36°C (rough estimate)
Density	1.4058 (rough estimate)
refractive index	1.5200 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO (up to 50 mg/ml).
form	Yellow to brown solid
color	Yellow
Sensitive	Light Sensitive
BRN	192350
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI	InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
CAS DataBase Reference	1485-00-3(CAS DataBase Reference)
NIST Chemistry Reference	3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)

Safety information for 3,4-Methylenedioxy-beta-nitrostyrene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.