3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Synonym(s):KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem;

CAS NO.：199666-03-0
Empirical Formula: C17H15N3O6S2
Molecular Weight: 421.45
MDL number: MFCD11040807
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Structural

What is 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide?

The Uses of 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.

What are the applications of Application

Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase (KMO) inhibitor

Definition

ChEBI: Ro 61-8048 is a C-nitro compound.

Biological Activity

Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.

Biochem/physiol Actions

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.

storage

+4°C

Properties of 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Melting point:	185℃
Boiling point:	627.4±65.0 °C(Predicted)
Density	1.471±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	DMSO: ≥15mg/mL
pka	6.29±0.10(Predicted)
form	Yellow solid
color	faint yellow to yellow

Safety information for 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

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