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HomeProduct name list3,4-DIHYDROISOQUINOLINE

3,4-DIHYDROISOQUINOLINE

  • CAS NO.:3230-65-7
  • Empirical Formula: C9H9N
  • Molecular Weight: 131.17
  • MDL number: MFCD00033714
  • EINECS: 221-769-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2022-12-21 16:56:50
3,4-DIHYDROISOQUINOLINE Structural

What is 3,4-DIHYDROISOQUINOLINE?

The Uses of 3,4-DIHYDROISOQUINOLINE

3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.

The Uses of 3,4-DIHYDROISOQUINOLINE

3,4-Dihydroisoquinoline can be used as a reactant to synthesize:

  • 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
  • 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
  • 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8

Properties of 3,4-DIHYDROISOQUINOLINE

Melting point: 251-254℃
Boiling point: 241.8±20.0℃ (760 Torr)
Density  1.05±0.1 g/cm3 (20 ºC 760 Torr)
refractive index  1.6041 (589.3 nm 30℃)
Flash point: 91.6±22.6℃
storage temp.  2-8°C
pka 5.80±0.20(Predicted)

Safety information for 3,4-DIHYDROISOQUINOLINE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H302:Acute toxicity,oral
H310:Acute toxicity,dermal
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P262:Do not get in eyes, on skin, or on clothing.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3,4-DIHYDROISOQUINOLINE

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