3,4-DIHYDROISOQUINOLINE

CAS NO.：3230-65-7
Empirical Formula: C9H9N
Molecular Weight: 131.17
MDL number: MFCD00033714
EINECS: 221-769-0
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-21 16:56:50

What is 3,4-DIHYDROISOQUINOLINE?

The Uses of 3,4-DIHYDROISOQUINOLINE

3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.

The Uses of 3,4-DIHYDROISOQUINOLINE

3,4-Dihydroisoquinoline can be used as a reactant to synthesize:

5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8

Properties of 3,4-DIHYDROISOQUINOLINE

Melting point:	251-254℃
Boiling point:	241.8±20.0℃ (760 Torr)
Density	1.05±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	1.6041 (589.3 nm 30℃)
Flash point:	91.6±22.6℃
storage temp.	2-8°C
pka	5.80±0.20(Predicted)

Safety information for 3,4-DIHYDROISOQUINOLINE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H302:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.