3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Synonym(s):7-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone;7-Hydroxy-3,4-dihydrocarbostyril
- CAS NO.：22246-18-0
- Empirical Formula: C9H9NO2
- Molecular Weight: 163.17
- MDL number: MFCD06410891
- EINECS: 239-784-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-05 18:22:57
What is 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone?
Chemical properties
Pale Yellow Powder
The Uses of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
3,4-Dihydro-7-hydroxyquinoline-2(1H)-one (Aripiprazole EP Impurity A) is an antitumor agent. Hydroxyindole analog inhibitor tyrosinase melanoma. This compound is also used in the preparation of aripiprazole (A771000).
Preparation
An improved process for preparing 7-hydroxy-3,4-dihydroquinolinone (7-HQ) by reacting N-(3-methoxyphenyl)-3-chloropropionamide (3-MPCA) with a Lewis acid, wherein 7-HQ is obtained having a purity greater than 98.5%, preferably greater than 99% and more preferably equal to or greater than 99.3%, without using chromatographic purification.
Properties of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Melting point: | 233-237 °C |
| Boiling point: | 403.7±45.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.60±0.20(Predicted) |
| color | Pale Yellow |
| CAS DataBase Reference | 22246-18-0(CAS DataBase Reference) |
Safety information for 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| InChIKey | LKLSFDWYIBUGNT-UHFFFAOYSA-N |
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone manufacturer
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