3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Synonym(s):7-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone;7-Hydroxy-3,4-dihydrocarbostyril
- CAS NO.：22246-18-0
- Empirical Formula: C9H9NO2
- Molecular Weight: 163.17
- MDL number: MFCD06410891
- EINECS: 239-784-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-10 20:44:46
What is 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone?
Chemical properties
Pale Yellow Powder
The Uses of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
3,4-Dihydro-7-hydroxyquinoline-2(1H)-one (Aripiprazole EP Impurity A) is an antitumor agent. Hydroxyindole analog inhibitor tyrosinase melanoma. This compound is also used in the preparation of aripiprazole (A771000).
Preparation
An improved process for preparing 7-hydroxy-3,4-dihydroquinolinone (7-HQ) by reacting N-(3-methoxyphenyl)-3-chloropropionamide (3-MPCA) with a Lewis acid, wherein 7-HQ is obtained having a purity greater than 98.5%, preferably greater than 99% and more preferably equal to or greater than 99.3%, without using chromatographic purification.
Properties of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Melting point: | 233-237 °C |
| Boiling point: | 403.7±45.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.60±0.20(Predicted) |
| color | Pale Yellow |
| CAS DataBase Reference | 22246-18-0(CAS DataBase Reference) |
Safety information for 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| InChIKey | LKLSFDWYIBUGNT-UHFFFAOYSA-N |
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone manufacturer
Neugen Labs
Karnataka
Phone:91-8133254502
Whatsapp: 91-8133254502
product: 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
ChemiSyn
Karnataka
Phone:91-9980188546
Whatsapp: 91-9980188546
product: 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
New Products
3-Oxocyclobutane-1-carboxylicacid 4-(Ethylaminomethyl)pyridine Ethyl 3-pyridylacetate 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Pyridin-4-ylmethanol hydrobromide Trans-methyl 4-aminocyclohexane- carboxylate HCl 1-Indanone 4-Chloro Phenyl hydrazine hydrochloride Nintedanib Ethanesulfonate (S)-2-(3,5-diMethylphenyl)pyrrolidine Ethyl 2-(4-(chlorosulfonyl)-2-methylphenoxy)acetate (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxylic acid (R)-1-phenylethan-1-amine salt 1-Bromo-2-Methoxy-3-Nitrobenzene N N N'Trimethyl ethylenediamine N Ethylmethylamine Ethyl Methanesulfonate Variamine Blue B Diazonium salt Lead II Bromide N N' DimethylEthylenediamine L-Glycine methyl ester.HCl Calcium Alphaketoglutarate* Fmoc-L-Glu(OtBu)-OH.H2O H-Ser(t-Bu)-Ser(t-Bu)-Gly-OH Fmoc-Ser(tBu)-Ser(Ψ(Me,Me)pro-OHRelated products of tetrahydrofuran
![7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one](https://img.chemicalbook.in/CAS/20200515/GIF/2060029-80-1.gif)
You may like
-
22246-18-0 98%View Details
22246-18-0 -
22246-18-0 7-Hydroxy 3,4-Dihydro Carbostyril 98%View Details
22246-18-0 -
3,4-dihydro-7-hydroxyquinolin-2(1H)-one 22246-18-0 98%View Details
22246-18-0 -
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 98%View Details -
Aripiprazole EP Impurity A 98%View Details
22246- 18-0 -
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 98%View Details -
7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline, 98% CAS 22246-18-0View Details
22246-18-0 -
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone CAS 22246-18-0View Details
22246-18-0
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.