3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE

CAS NO.：5439-14-5
Empirical Formula: C8H8N2O
Molecular Weight: 148.16
MDL number: MFCD00042798
EINECS: 226-618-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-14 17:31:13

What is 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE?

Purification Methods

Dissolve it in CHCl3, filter, evaporate, then recrystallise the residue from EtOH/Me2CO (needles) which can be washed with Et2O and dried. It can also be recrystallised from CHCl3/pet ether or CHCl3/hexane. The hydrochloride has m 295-295o (dec, from EtOH or MeOH/Et2O), the hydrobromide has m 299-300o(dec) (from MeOH/Et2O) and the picrate has m 224-226o(corr), m 219-220o from EtOH. [Adams & Pachter J Am Chem Soc 74 4906 1952, Lappin J Org Chem 23 1358 1958, Hurd & Hayao J Am Chem Soc 77 115 1955, Beilstein 24 III/IV 299.]

Properties of 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE

Melting point:	185-187 °C
Boiling point:	271℃
Density	1.26
Flash point:	118℃
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	2.83±0.20(Predicted)
color	Light Yellow
BRN	3667723

Safety information for 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.