3-(TRIFLUOROACETYL)INDOLE

Synonym(s):3-Indolyl trifluoromethyl ketone

CAS NO.：14618-45-2
Empirical Formula: C10H6F3NO
Molecular Weight: 213.16
MDL number: MFCD00182114
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 3-(TRIFLUOROACETYL)INDOLE?

The Uses of 3-(TRIFLUOROACETYL)INDOLE

Reactant for enantioselective synthesis of indoles via palladium-catalyzed kinetic asymmetrical alkylation. Reactant for preparation of N-pyridinyl indolecarboxamides via amidation of aminopyridine derivatives. with indolecarboxylic acid 2 Reactant for preparation of mast cell tryptase inhibitors, starting from indoles; using amidation as the key step 3 Reactant for formation of Michael adducts via Baylis-Hillman reaction 4 Reactant for preparation of indolecarboxamides via haloform cleavage of (trifluoroacetyl)indole with lithium dialkylamides.

The Uses of 3-(TRIFLUOROACETYL)INDOLE

Reactant for enantioselective synthesis of indoles via palladium-catalyzed kinetic asymmetrical alkylation
Reactant for preparation of N-pyridinyl indolecarboxamides via amidation of aminopyridine derivatives. with indolecarboxylic acid
Reactant for preparation of mast cell tryptase inhibitors, starting from indoles; using amidation as the key step
Reactant for formation of Michael adducts via Baylis-Hillman reaction
Reactant for preparation of indolecarboxamides via haloform cleavage of (trifluoroacetyl)indole with lithium dialkylamides

General Description

3-(Trifluoroacetyl)indole is a heterocyclic trifluoromethyl ketone. One of the methods reported for its synthesis is by the reaction of indole with trifluoroacetic anhydride.

Properties of 3-(TRIFLUOROACETYL)INDOLE

Melting point:	211-214 °C(lit.)
Boiling point:	308.6±37.0 °C(Predicted)
Density	1.423±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	Solid
pka	14.31±0.30(Predicted)
color	White to Almost white
CAS DataBase Reference	14618-45-2(CAS DataBase Reference)

Safety information for 3-(TRIFLUOROACETYL)INDOLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.