3-Pyridinecarboxaldehyde
Synonym(s):Nicotinaldehyde
- CAS NO.:500-22-1
- Empirical Formula: C6H5NO
- Molecular Weight: 107.11
- MDL number: MFCD00006382
- EINECS: 207-900-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-20 17:27:21
What is 3-Pyridinecarboxaldehyde ?
Description
Pyridine-3-carbaldehyde, also known as nicotinaldehyde or 3-Pyridinecarboxaldehyde, belongs to the class of organic compounds known as pyridine carboxaldehydes. These are aromatic compounds containing a pyridine ring which bears a carboxaldehyde group. 3-pyridinecarboxaldehyde is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Pyridine-3-carbaldehyde, an aldehyde containing a nitrogen atom, reacts faster than benzaldehyde with diethylzinc to afford enantioenriched 3-pyridyl alkanol in a reaction in which the same chiral catalyst, i.e., (1S,2R)-N, N-dibutylnorephedrine, is used.
Chemical properties
clear yellow to light brown liquid
The Uses of 3-Pyridinecarboxaldehyde
3-Pyridinecarboxaldehyde is a substituted pyridine with niacin activity. 3-Pyridinecarboxaldehyde is a component of tobacco smoke.
Definition
ChEBI: A pyridinecarbaldehyde that is pyridine substituted by a formyl group at position 3.
Synthesis Reference(s)
Synthetic Communications, 21, p. 1777, 1991 DOI: 10.1080/00397919108021576
Tetrahedron, 32, p. 2549, 1976 DOI: 10.1016/0040-4020(76)88025-8
Tetrahedron Letters, 35, p. 8019, 1994 DOI: 10.1016/0040-4039(94)80038-3
Preparation
3-Pyridinecarboxaldehyde can be produced from nicotinonitrile. Alternatively, it arises by the aerobic oxidation of the corresponding alcohol.
Hazards
3-Pyridinecarboxaldehyde is a severe skin irritant.
Purification Methods
Purified as for pyridine-2-aldehyde. [Beilstein 21 I 288, 21 III/IV 3517, 21/7 V 334.]
Properties of 3-Pyridinecarboxaldehyde
Melting point: | 8°C |
Boiling point: | 78-81 °C/10 mmHg (lit.) |
Density | 1.141 g/mL at 20 °C (lit.) |
vapor pressure | 0.3 hPa (20 °C) |
refractive index | n |
Flash point: | 140 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
pka | 3.43±0.10(Predicted) |
form | liquid (clear) |
color | clear brown-yellow |
Specific Gravity | 1.145 (20/4℃) |
PH | 5.4 (111g/l, H2O, 20℃) |
Water Solubility | miscible |
Sensitive | Air Sensitive |
BRN | 105343 |
CAS DataBase Reference | 500-22-1(CAS DataBase Reference) |
NIST Chemistry Reference | 3-Pyridinecarboxaldehyde(500-22-1) |
EPA Substance Registry System | 3-Pyridinecarboxaldehyde (500-22-1) |
Safety information for 3-Pyridinecarboxaldehyde
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 3-Pyridinecarboxaldehyde
InChIKey | QJZUKDFHGGYHMC-UHFFFAOYSA-N |
Abamectin manufacturer
Manik Laboratories
CHROMOSYNTH PVT LTD
RPN ORGANICS PVT LTD
JSK Chemicals
Vepan Pharmatech Pvt Ltd
ARRKEM LIFE SCIENCES PRIVATE LIMITED
Anami Organics
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