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HomeProduct name list3-Pyridinecarboxaldehyde

3-Pyridinecarboxaldehyde

Synonym(s):Nicotinaldehyde

  • CAS NO.:500-22-1
  • Empirical Formula: C6H5NO
  • Molecular Weight: 107.11
  • MDL number: MFCD00006382
  • EINECS: 207-900-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-20 17:27:21
3-Pyridinecarboxaldehyde  Structural

What is 3-Pyridinecarboxaldehyde ?

Description

Pyridine-3-carbaldehyde, also known as nicotinaldehyde or 3-Pyridinecarboxaldehyde, belongs to the class of organic compounds known as pyridine carboxaldehydes. These are aromatic compounds containing a pyridine ring which bears a carboxaldehyde group. 3-pyridinecarboxaldehyde is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Pyridine-3-carbaldehyde, an aldehyde containing a nitrogen atom, reacts faster than benzaldehyde with diethylzinc to afford enantioenriched 3-pyridyl alkanol in a reaction in which the same chiral catalyst, i.e., (1S,2R)-N, N-dibutylnorephedrine, is used.

Chemical properties

clear yellow to light brown liquid

The Uses of 3-Pyridinecarboxaldehyde

3-Pyridinecarboxaldehyde is a substituted pyridine with niacin activity. 3-Pyridinecarboxaldehyde is a component of tobacco smoke.

Definition

ChEBI: A pyridinecarbaldehyde that is pyridine substituted by a formyl group at position 3.

Synthesis Reference(s)

Synthetic Communications, 21, p. 1777, 1991 DOI: 10.1080/00397919108021576
Tetrahedron, 32, p. 2549, 1976 DOI: 10.1016/0040-4020(76)88025-8
Tetrahedron Letters, 35, p. 8019, 1994 DOI: 10.1016/0040-4039(94)80038-3

Preparation

3-Pyridinecarboxaldehyde can be produced from nicotinonitrile. Alternatively, it arises by the aerobic oxidation of the corresponding alcohol.

Hazards

3-Pyridinecarboxaldehyde is a severe skin irritant.

Purification Methods

Purified as for pyridine-2-aldehyde. [Beilstein 21 I 288, 21 III/IV 3517, 21/7 V 334.]

Properties of 3-Pyridinecarboxaldehyde

Melting point: 8°C
Boiling point: 78-81 °C/10 mmHg (lit.)
Density  1.141 g/mL at 20 °C (lit.)
vapor pressure  0.3 hPa (20 °C)
refractive index  n20/D 1.549(lit.)
Flash point: 140 °F
storage temp.  2-8°C
solubility  Chloroform (Sparingly), Methanol (Slightly)
pka 3.43±0.10(Predicted)
form  liquid (clear)
color  clear brown-yellow
Specific Gravity 1.145 (20/4℃)
PH 5.4 (111g/l, H2O, 20℃)
Water Solubility  miscible
Sensitive  Air Sensitive
BRN  105343
CAS DataBase Reference 500-22-1(CAS DataBase Reference)
NIST Chemistry Reference 3-Pyridinecarboxaldehyde(500-22-1)
EPA Substance Registry System 3-Pyridinecarboxaldehyde (500-22-1)

Safety information for 3-Pyridinecarboxaldehyde

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for 3-Pyridinecarboxaldehyde

InChIKey QJZUKDFHGGYHMC-UHFFFAOYSA-N

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