3-METHYLTHIOPHENE-2-CARBONITRILE

CAS NO.：55406-13-8
Empirical Formula: C6H5NS
Molecular Weight: 123.18
MDL number: MFCD00052086
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-30 16:20:48

What is 3-METHYLTHIOPHENE-2-CARBONITRILE?

Preparation

3-Methylthiophene-2-carbonitrile synthesis: 3-Methyl-2-thiophenecarboxamide (18.6 g, 0.13 mol) was mixed with an excess of POCl3, and the mixture heated at reflux temperature for 2 h. The excess POCl3 was removed under vacuum and the residue dissolved in 500 mL of 1,2-dichloroethane, washed (carefully!) with water, then brine, and the solvent removed to give 23 g of crude 3-methyl-2-thiophenecarbonitrile. This material was passed through a plug of silica gel with CH2Cl2 and the solvent evaporated to give 16.2 g (100%) of as a light tan oil: 1H NMR (CDCl3) d 7.4 (d, J=4.8 Hz, 1H), 6.9 (d, J=5.4 Hz, 1H), 2.4 ppm (s, 3H); 97% pure by HPLC area %.

Properties of 3-METHYLTHIOPHENE-2-CARBONITRILE

Boiling point:	91-93°C 12mm
refractive index	1.5530
Flash point:	91-93°C/12mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
BRN	5495606
CAS DataBase Reference	55406-13-8(CAS DataBase Reference)

Safety information for 3-METHYLTHIOPHENE-2-CARBONITRILE

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up.