3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine

CAS NO.：330819-85-7
Empirical Formula: C10H11N3S2
Molecular Weight: 237.34
Update Date: 2023-05-21 10:59:17

What is 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine?

Description

VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; K_i = 1.07 μM).¹ It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC₅₀ = 1.7 μM).

References

1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78(6),1105-1123(2010).

Properties of 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine

storage temp.	Store at -20°C
solubility	DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 20mg/mL; PBS (pH 7.2): insolube
form	A crystalline solid

Safety information for 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine

Computed Descriptors for 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine

New Products

4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acid

Related products of tetrahydrofuran

VU-29

VU0661013

VU0650786

VU 0364439

VU 0360223

VU 0357121

VU 0365114

VU 0360172