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HomeProduct name listVU 0364439

VU 0364439

VU 0364439 Structural

What is VU 0364439?

The Uses of VU 0364439

VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2).

What are the applications of Application

VU 0364439 is a positive allosteric modulator (PAM) of mGluR-4

References

[1]. lucyna pomierny-chamioło, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178.

Properties of VU 0364439

Density  1.538±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  ≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form  solid
pka 7.71±0.10(Predicted)
color  White to off-white

Safety information for VU 0364439

Computed Descriptors for VU 0364439

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