3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
- CAS NO.：306387-90-6
- Empirical Formula: C44H63N3O4
- Molecular Weight: 697.999
- MDL number: MFCD03425585
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine?
Chemical properties
Pale Yellow Solid
The Uses of 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.KAAD-Cyclopamine compound is unstable in solution.
The Uses of 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression i
What are the applications of Application
A specific inihibtor of hedgehog signaling
Properties of 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
| Boiling point: | 875.6±65.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform: Slightly soluble; Methanol: Slightly soluble |
| form | A solid |
| pka | 16.10±0.46(Predicted) |
| color | White to light yellow |
| CAS DataBase Reference | 306387-90-6 |
Safety information for 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
Computed Descriptors for 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
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