3-Indoleacrylic acid
Synonym(s):3-(3-Indolyl)acrylic acid;IAA
- CAS NO.:1204-06-4
- Empirical Formula: C11H9NO2
- Molecular Weight: 187.19
- MDL number: MFCD00005633
- EINECS: 214-872-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:32
What is 3-Indoleacrylic acid?
Chemical properties
light yellow to yellow-beige crystalline powder
The Uses of 3-Indoleacrylic acid
3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.
What are the applications of Application
3-Indoleacrylic acid is which induces transcription of genes under the control of the trpE promoter
Definition
ChEBI: (E)-3-(indol-3-yl)acrylic acid is an alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which one of the hydrogens at position 3 is replaced by an indol-3-yl group. It is an alpha,beta-unsaturated monocarboxylic acid and a member of indoles. It is functionally related to an acrylic acid. It is a conjugate acid of an (E)-3-(indol-3-yl)acrylate(1-).
Synthesis Reference(s)
Synthesis, p. 236, 1984 DOI: 10.1055/s-1984-30787
General Description
3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.
Biochem/physiol Actions
3-Indoleacrylic acid helps to block the mycelial growth of?Neurospora crassa. As a result, the cells accumulate indoleglycerol phosphate, which influences the rate of tryptophan synthetase.
Purification Methods
Recrystallise the acid from AcOH, H2O or EtOAc/cyclohexane. UV in MeOH has at 225, 274 and 325nm. [Shaw et al. J Org Chem 23 1171 1958, constitution: Rappe Acta max Chem Scand 18 818 1964, Moffatt J Chem Soc 1442 1957, Kimming et al. Hoppe Seyler's Z Physiol Chem 371 234 1958, Beilstein 22 V 249.]
Properties of 3-Indoleacrylic acid
Melting point: | 185 °C (dec.)(lit.) |
Boiling point: | 321.94°C (rough estimate) |
Density | 1.1963 (rough estimate) |
refractive index | 1.4900 (estimate) |
storage temp. | room temp |
form | powder |
pka | 4.59±0.10(Predicted) |
color | white to light yellow |
Water Solubility | freely soluble |
BRN | 6317 |
CAS DataBase Reference | 1204-06-4(CAS DataBase Reference) |
EPA Substance Registry System | 2-Propenoic acid, 3-(1H-indol-3-yl)- (1204-06-4) |
Safety information for 3-Indoleacrylic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Indoleacrylic acid
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