3-HYDROXY-3-PHENYL-PROPIONITRILE
Synonym(s):β-Hydroxy-benzenepropanenitrile
- CAS NO.：17190-29-3
- Empirical Formula: C9H9NO
- Molecular Weight: 147.17
- MDL number: MFCD00544189
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:02
What is 3-HYDROXY-3-PHENYL-PROPIONITRILE?
Chemical properties
Orange Oil
The Uses of 3-HYDROXY-3-PHENYL-PROPIONITRILE
3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.
Definition
ChEBI: 3-hydroxy-3-phenylpropionitrile is a nitrile that is 3-phenylpropionitrile in which one of the methylene hydrogens at position 3 is replaced by a hydroxy group. It is a nitrile, a member of benzyl alcohols and a secondary alcohol. It is functionally related to a 3-phenylpropionitrile.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 366, 1983 DOI: 10.1021/jo00151a017
Synthetic Communications, 24, p. 1433, 1994 DOI: 10.1080/00397919408011747
Tetrahedron Letters, 26, p. 155, 1985 DOI: 10.1016/S0040-4039(00)61867-1
General Description
3-Hydroxy-3-phenylpropionitrile, a β-hydroxynitrile, is an aryl substituted α-aminophenylaceronitrile. It can be obtained by reacting lithioacetonitrile with benzaldehyde via asymmetric 1,2-addition reaction.
Properties of 3-HYDROXY-3-PHENYL-PROPIONITRILE
| Boiling point: | 306-307 °C (lit.) |
| Density | 1.112 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Chloroform, Dichloromethane, Ethyl Acetate |
| pka | 13.00±0.20(Predicted) |
| color | Colourless |
Safety information for 3-HYDROXY-3-PHENYL-PROPIONITRILE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 3-HYDROXY-3-PHENYL-PROPIONITRILE
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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