3-HYDROXY-3-PHENYL-PROPIONITRILE

Synonym(s):β-Hydroxy-benzenepropanenitrile

CAS NO.：17190-29-3
Empirical Formula: C9H9NO
Molecular Weight: 147.17
MDL number: MFCD00544189
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:02

3-HYDROXY-3-PHENYL-PROPIONITRILE Structural

What is 3-HYDROXY-3-PHENYL-PROPIONITRILE?

Chemical properties

Orange Oil

The Uses of 3-HYDROXY-3-PHENYL-PROPIONITRILE

3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.

Definition

ChEBI: 3-hydroxy-3-phenylpropionitrile is a nitrile that is 3-phenylpropionitrile in which one of the methylene hydrogens at position 3 is replaced by a hydroxy group. It is a nitrile, a member of benzyl alcohols and a secondary alcohol. It is functionally related to a 3-phenylpropionitrile.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 366, 1983 DOI: 10.1021/jo00151a017
Synthetic Communications, 24, p. 1433, 1994 DOI: 10.1080/00397919408011747
Tetrahedron Letters, 26, p. 155, 1985 DOI: 10.1016/S0040-4039(00)61867-1

General Description

3-Hydroxy-3-phenylpropionitrile, a β-hydroxynitrile, is an aryl substituted α-aminophenylaceronitrile. It can be obtained by reacting lithioacetonitrile with benzaldehyde via asymmetric 1,2-addition reaction.

Properties of 3-HYDROXY-3-PHENYL-PROPIONITRILE

Boiling point:	306-307 °C (lit.)
Density	1.112 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5420(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,2-8°C
solubility	soluble in Chloroform, Dichloromethane, Ethyl Acetate
pka	13.00±0.20(Predicted)
color	Colourless

Safety information for 3-HYDROXY-3-PHENYL-PROPIONITRILE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.