3-Hydroxy-2-nitropyridine
Synonym(s):2-Nitro-3-pyridinol
- CAS NO.:15128-82-2
- Empirical Formula: C5H4N2O3
- Molecular Weight: 140.1
- MDL number: MFCD00006258
- EINECS: 239-191-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 19:00:21
What is 3-Hydroxy-2-nitropyridine?
Chemical properties
yellow crystalline powder
The Uses of 3-Hydroxy-2-nitropyridine
3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization.
Preparation
Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%.
Properties of 3-Hydroxy-2-nitropyridine
Melting point: | 69-71 °C (lit.) |
Boiling point: | 256.56°C (rough estimate) |
Density | 1.5657 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
pka | 0.31±0.22(Predicted) |
form | Crystalline Powder |
color | Yellow |
BRN | 124473 |
CAS DataBase Reference | 15128-82-2(CAS DataBase Reference) |
EPA Substance Registry System | 3-Hydroxy-2-nitropyridine (15128-82-2) |
Safety information for 3-Hydroxy-2-nitropyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Hydroxy-2-nitropyridine
InChIKey | QBPDSKPWYWIHGA-UHFFFAOYSA-N |
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