3-Hydroxy-2-nitropyridine
Synonym(s):2-Nitro-3-pyridinol
- CAS NO.:15128-82-2
- Empirical Formula: C5H4N2O3
- Molecular Weight: 140.1
- MDL number: MFCD00006258
- EINECS: 239-191-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is 3-Hydroxy-2-nitropyridine?
Chemical properties
yellow crystalline powder
The Uses of 3-Hydroxy-2-nitropyridine
3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization.
Preparation
Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%.
Properties of 3-Hydroxy-2-nitropyridine
Melting point: | 69-71 °C (lit.) |
Boiling point: | 256.56°C (rough estimate) |
Density | 1.5657 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
pka | 0.31±0.22(Predicted) |
form | Crystalline Powder |
color | Yellow |
BRN | 124473 |
CAS DataBase Reference | 15128-82-2(CAS DataBase Reference) |
EPA Substance Registry System | 3-Hydroxy-2-nitropyridine (15128-82-2) |
Safety information for 3-Hydroxy-2-nitropyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Hydroxy-2-nitropyridine
InChIKey | QBPDSKPWYWIHGA-UHFFFAOYSA-N |
3-Hydroxy-2-nitropyridine manufacturer
chemmolelaboratories private limited
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
GRK RESEARCH LABORATORIES PVT LTD
RPN ORGANICS PVT LTD
Sintilla Medcoms Pvt Ltd
Stereokem Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
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