3-HYDRAZINO-QUINOXALINE-2-THIOL

CAS NO.：13080-21-2
Empirical Formula: C8H8N4S
Molecular Weight: 192.24
MDL number: MFCD00457014
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is 3-HYDRAZINO-QUINOXALINE-2-THIOL?

Biological Activity

HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.

in vitro

The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T _1/2 of 1.3 hours) and the ability to passively permeate membranes.

Properties of 3-HYDRAZINO-QUINOXALINE-2-THIOL

Melting point:	254 °C (decomp)(Solv: ethanol (64-17-5))
Boiling point:	376.1±25.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
pka	7.91±0.20(Predicted)
form	Solid
color	Light yellow to yellow

Safety information for 3-HYDRAZINO-QUINOXALINE-2-THIOL

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up.