3-Chlorophenol

Synonym(s):3-Chlorophenol

CAS NO.：108-43-0
Empirical Formula: C6H5ClO
Molecular Weight: 128.56
MDL number: MFCD00002256
EINECS: 203-582-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is 3-Chlorophenol?

Chemical properties

White to light yellow crystal.

Chemical properties

All isomers have a characteristic odor.

The Uses of 3-Chlorophenol

3-Chlorophenol is a halophenol with antifungal activity. 3-Chlorophenol is commonly used as a building block in the preparation of variety of biologically active compounds. Studies suggest that 3-Chlo rophenol can be used in the regeneration of vegetal activated carbons.

The Uses of 3-Chlorophenol

3-Chlorophenol is widely used in the pharmaceutical, dyes and organic synthesis industry. It is an important intermediate in the synthesis of chemicals.

The Uses of 3-Chlorophenol

3-Chlorophenol is generally used in building various polycyclic aromatic systems. It is also employed in palladium-catalyzed coupling reactions to synthesize aryl intermediates in synthetic organic chemistry.

Definition

ChEBI: 3-chlorophenol is a monochlorophenol carrying the chloro substituent at position 3.

General Description

White crystals with an odor of phenol. Sinks in and slowly dissolves in water.

Air & Water Reactions

Discolors on exposure to air. Water soluble

Reactivity Profile

3-Chlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents .

Hazard

Toxic by skin absorption, inhalation, or ingestion.

Fire Hazard

3-Chlorophenol is probably combustible.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Flammable or combustible liquid. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS.

Potential Exposure

Monochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.

Shipping

UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It could not be obtained solid by crystallisation from pet ether. It is best purified by distillation under reduced pressure. [Beilstein 6 IV 810.]

Incompatibilities

May form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.

Waste Disposal

Incinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.

Properties of 3-Chlorophenol

Melting point:	31-34 °C (lit.)
Boiling point:	214 °C (lit.)
Density	1.218 g/mL at 25 °C (lit.)
vapor pressure	1 hPa (44 °C)
refractive index	n20/D 1.563(lit.)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	Soluble in ethanol and ether.
form	Liquid After Melting
pka	8.85(at 25℃)
color	Clear yellow to brownish
PH	3.5 (27.7g/l, H2O, 20℃)
Odor	distinct phenol-like odor
Water Solubility	27.7 g/L (20 ºC)
Merck	14,2154
BRN	1634401
Stability:	Stable. Combustible. Incompatible with acid chlorides, oxidizing agents, acid anhydrides. Discolours in air.
CAS DataBase Reference	108-43-0(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 3-chloro-(108-43-0)
EPA Substance Registry System	m-Chlorophenol (108-43-0)

Safety information for 3-Chlorophenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.