3-Chloro-4-fluoronitrobenzene

Synonym(s):2-Chloro-1-fluoro-4-nitrobenzene

CAS NO.：350-30-1
Empirical Formula: C6H3ClFNO2
Molecular Weight: 175.54
MDL number: MFCD00007206
EINECS: 206-499-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-25 17:47:29

3-Chloro-4-fluoronitrobenzene Structural

What is 3-Chloro-4-fluoronitrobenzene?

Chemical properties

white to light yellow crystal powder

The Uses of 3-Chloro-4-fluoronitrobenzene

2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.

The Uses of 3-Chloro-4-fluoronitrobenzene

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

benzoimidolones on Ameba resin
methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)₆ and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

Properties of 3-Chloro-4-fluoronitrobenzene

Melting point:	40-42 °C(lit.)
Boiling point:	227-232°C
Density	1.61
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
color	White to Light yellow to Green
BRN	1944997
CAS DataBase Reference	350-30-1(CAS DataBase Reference)
NIST Chemistry Reference	3-Chloro-4-fluoronitrobenzene(350-30-1)
EPA Substance Registry System	3-Chloro-4-fluoronitrobenzene (350-30-1)

Safety information for 3-Chloro-4-fluoronitrobenzene

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.