3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Synonym(s):1-Methylnicotinamide chloride;3-Carbamyl-1-methylpyridinium chloride;MNA;N1-Methylnicotinamide chloride;N-Methylnicotinic acid amide chloride
- CAS NO.:1005-24-9
- Empirical Formula: C7H9ClN2O
- Molecular Weight: 172.61
- MDL number: MFCD00060042
- EINECS: 463-670-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE?
Description
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
The Uses of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
The Uses of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
What are the applications of Application
1-Methylnicotinamide chloride is a metabolite of nicotinamide that serves a role in modulating cellular redox status and controlling signaling and transcriptional events.
General Description
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
Purification Methods
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
Properties of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Melting point: | 207-209℃ (water acetone ) |
storage temp. | room temp |
solubility | H2O: soluble15mg/mL, clear |
form | crystalline |
color | white |
Water Solubility | almost transparency |
Merck | 14,9693 |
CAS DataBase Reference | 1005-24-9(CAS DataBase Reference) |
Safety information for 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
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