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HomeProduct name list3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Synonym(s):1-Methylnicotinamide chloride;3-Carbamyl-1-methylpyridinium chloride;MNA;N1-Methylnicotinamide chloride;N-Methylnicotinic acid amide chloride

  • CAS NO.:1005-24-9
  • Empirical Formula: C7H9ClN2O
  • Molecular Weight: 172.61
  • MDL number: MFCD00060042
  • EINECS: 463-670-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Structural

What is 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE?

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

The Uses of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

The Uses of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).

What are the applications of Application

1-Methylnicotinamide chloride is a metabolite of nicotinamide that serves a role in modulating cellular redox status and controlling signaling and transcriptional events.

General Description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Purification Methods

Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

Properties of 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Melting point: 207-209℃ (water acetone )
storage temp.  room temp
solubility  H2O: soluble15mg/mL, clear
form  crystalline
color  white
Water Solubility  almost transparency
Merck  14,9693
CAS DataBase Reference 1005-24-9(CAS DataBase Reference)

Safety information for 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

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