3-Butyn-1-ol

CAS NO.：927-74-2
Empirical Formula: C4H6O
Molecular Weight: 70.09
MDL number: MFCD00002955
EINECS: 213-161-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-28 19:50:54

What is 3-Butyn-1-ol?

Chemical properties

colourless liquid

The Uses of 3-Butyn-1-ol

(3-Butyn-1-ol) Alkynyl substrate used in a study of a palladium-catalyzed coupling with β-tetrionic acid bromide leading to alkynyl substituted furanones in good yield.1

The Uses of 3-Butyn-1-ol

3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.

The Uses of 3-Butyn-1-ol

Synthon for preparation of oxygen-containing heterocycles and protected esters of s-Hydroxy-L-isoleucine

Definition

ChEBI: A terminal acetylenic compound that is but-1-yne with one of the methyl hydrogens substituted by a hydroxy group.

General Description

The enthalpies of combustion and vaporization of 3-butyn-1-ol is measured by static bomb combustion calorimetry and correlation gas chromatography techniques.

Properties of 3-Butyn-1-ol

Melting point:	-63.6 °C (lit.)
Boiling point:	128.9 °C (lit.)
Density	0.926 g/mL at 25 °C (lit.)
refractive index	n20/D 1.441(lit.)
Flash point:	97 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Miscible with alcohols and organic solvents. Immiscible with aliphatic hydrocarbon solvents.
form	Liquid
pka	14.22±0.10(Predicted)
color	Clear colorless to light yellow
Specific Gravity	0.972
BRN	773710
Stability:	Stable. Substances to be avoided include oxidizing agents, acids and acid anhydrides, copper and copper alloys. Flammable.
CAS DataBase Reference	927-74-2(CAS DataBase Reference)
NIST Chemistry Reference	3-Butyn-1-ol(927-74-2)
EPA Substance Registry System	3-Butyn-1-ol (927-74-2)

Safety information for 3-Butyn-1-ol

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.