3-BROMO-4-CHLORO-BENZALDEHYDE
- CAS NO.:86265-88-5
- Empirical Formula: C7H4BrClO
- Molecular Weight: 219.46
- MDL number: MFCD08059100
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 3-BROMO-4-CHLORO-BENZALDEHYDE?
The Uses of 3-BROMO-4-CHLORO-BENZALDEHYDE
3-BROMO-4-CHLORO-BENZALDEHYDE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
The product from above (3.4 g, 22 mmol) in concentrated 48% aqueous HBr (20 mL) at 0 ??C was treated with a 0 ??C solution of NaNO2 (1.5 g, 22 mmol) in water (30 mL). The reaction mixture was stirred for 30 min and then transferred cold to a stirred solution of CuBr (4.44 g, 31 mmol) in 48% aqueous HBr (20 mL) at 23 ??C (significant frothing!). Water (40 mL) was added, the solution was heated at 60 ??C for 45 min, cooled, diluted with EtOAc (200 mL) and water (50 mL), and the layers were separated. The aqueous layer was extracted with EtOAc (2x, 50 mL). The organic layers were combined, washed with 1 M HCl (2x, 100 mL) and brine (50 mL), dried (Na2SO4), filtered, and concentrated to provide 3-bromo-4-chlorobenzaldehyde as a pale yellow powder (3.9 g, 82%). 3-Bromo-4-chlorobenzaldehyde, yield 3.9 g, 82%
Properties of 3-BROMO-4-CHLORO-BENZALDEHYDE
Melting point: | 70℃ |
Boiling point: | 277.8±20.0℃ (760 Torr) |
Density | 1.698±0.06 g/cm3 (20 ºC 760 Torr) |
Flash point: | 121.8±21.8℃ |
storage temp. | Inert atmosphere,2-8°C |
color | White |
Safety information for 3-BROMO-4-CHLORO-BENZALDEHYDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-BROMO-4-CHLORO-BENZALDEHYDE
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