3-Bromo-3,3-difluoropropene
- CAS NO.:420-90-6
- Empirical Formula: C3H3BrF2
- Molecular Weight: 156.96
- MDL number: MFCD00042185
- EINECS: 810-594-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 3-Bromo-3,3-difluoropropene?
The Uses of 3-Bromo-3,3-difluoropropene
3-Bromo-3,3-difluoropropene, when mixed with lithium bromide, provides a convenient route to prepare gem-(difluoroallyl) lithium, a reagent of general use in the formation of gem-difluorinated organic compounds. Umpolung asymmetric difluoroallylation of hydrazones with 3-bromo-3,3-difluoropropene (BDFP) under palladium catalysis. In addition, aldehydes and ketones reacted with 3-bromo-3,3-difluoropropene in the presence of the acid-washed zinc powder at 0°C to room temperature to afford gem-difluorohomoallyl alcohols in moderate yields[1-3].
References
[1] Shuai Huang. “Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand.” Nature Communications 12 1 (2021): 6551.
[2] J.D. Langridge, S.A. Cooke, B.E. Long. “The microwave spectra, bromine nuclear electric quadrupole coupling tensor, and structure of 3-bromo-3,3-difluoropropene.” Journal of Molecular Structure 1000 1 (2011): Pages 24-28.
[3] M. Kirihara. “Indium-Mediated Reaction of 3-Bromo-3,3-difluoropropene and Bromodifluoromethylacetylene Derivatives with Aldehydes.” ChemInform 3 1 (2001).
Properties of 3-Bromo-3,3-difluoropropene
Melting point: | 53-54°C |
Boiling point: | 41-42°C |
Density | 1,543 g/cm3 |
refractive index | 1.377 |
storage temp. | Keep Cold |
form | clear liquid |
color | Colorless to Light yellow |
Specific Gravity | 1.543 |
CAS DataBase Reference | 420-90-6(CAS DataBase Reference) |
Safety information for 3-Bromo-3,3-difluoropropene
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Bromo-3,3-difluoropropene
InChIKey | GDDNTTHUKVNJRA-UHFFFAOYSA-N |
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