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HomeProduct name list3-Acetylindole

3-Acetylindole

Synonym(s):3-Indolyl methyl ketone;NSC 47180;NSC 58084

  • CAS NO.:703-80-0
  • Empirical Formula: C10H9NO
  • Molecular Weight: 159.18
  • MDL number: MFCD00005626
  • EINECS: 211-875-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
3-Acetylindole Structural

What is 3-Acetylindole?

Chemical properties

yellow to light brown powder

The Uses of 3-Acetylindole

3-Acetylindole can be used as anti-fungal agents.

The Uses of 3-Acetylindole

Reactant for preparation of:• ;Indole derivatives as antitumor agents1• ;Endothelin-1 antagonists2• ;Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities3• ;Inhibitors of hepatitis C NS3/4A serine protease4• ;Antibacterial agens against MDR Staphylococcus aureus strains5• ;Antimalarial agents6• ;Anti-bovine viral diarrhea virus (BVDV) agents7• ;HIV-1 integrase inhibitors8• ;Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release9

The Uses of 3-Acetylindole

Reactant for preparation of:

  • Indole derivatives as antitumor agents
  • Endothelin-1 antagonists
  • Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
  • Inhibitors of hepatitis C NS3/4A serine protease
  • Antibacterial agens against MDR Staphylococcus aureus strains
  • Antimalarial agents
  • Anti-bovine viral diarrhea virus (BVDV) agents
  • HIV-1 integrase inhibitors
  • Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release

Purification Methods

Recrystallise the indole from MeOH or *C6H6 containing a little EtOH. The phenylureido derivative has m 154o. [Baker J Chem Soc 461 1946, Beilstein 21/8 V 297.]

Properties of 3-Acetylindole

Melting point: 188-192 °C (lit.)
Boiling point: 284.68°C (rough estimate)
Density  1.1202 (rough estimate)
refractive index  1.6070 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO; Dichloromethane; Methanol;
form  Powder
pka 15.38±0.30(Predicted)
color  Yellow to light brown
BRN  122579
CAS DataBase Reference 703-80-0(CAS DataBase Reference)
NIST Chemistry Reference Ethanone, 1-(1h-indol-3-yl)-(703-80-0)

Safety information for 3-Acetylindole

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242:Use only non-sparking tools.
P243:Take precautionary measures against static discharge.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for 3-Acetylindole

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