3-(2,4-dimethoxybenzylidene)anabaseine
- CAS NO.：156223-05-1
- Empirical Formula: C19H22Cl2N2O2
- Molecular Weight: 0
- MDL number: MFCD00941364
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is 3-(2,4-dimethoxybenzylidene)anabaseine?
The Uses of 3-(2,4-dimethoxybenzylidene)anabaseine
GTS-21 has been used:
- as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages
- to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)
- to test its effect on microvascular inflammation?in endotoxemia induced by LPS
Biochem/physiol Actions
GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.
Properties of 3-(2,4-dimethoxybenzylidene)anabaseine
| Melting point: | 216-217℃ (decomposition) |
| storage temp. | 2-8°C |
| solubility | H2O: >5mg/mL |
| form | powder |
| color | faint yellow to dark yellow |
Safety information for 3-(2,4-dimethoxybenzylidene)anabaseine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-(2,4-dimethoxybenzylidene)anabaseine
| InChIKey | RPYWXZCFYPVCNQ-RVDMUPIBSA-N |
New Products
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