(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
Synonym(s):(R,R)-Chiraphos
- CAS NO.：74839-84-2
- Empirical Formula: C28H28P2
- Molecular Weight: 426.48
- MDL number: MFCD00075403
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-11 17:26:00
What is (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE?
Chemical properties
white crystalline powder
The Uses of (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
(2R,3R)-Bis(diphenylphosphino)butane is a reagent used in the synthesis of endothelin A receptor antagonists. Also used in the synthesis of (R)-Tolterodine and (S)-Tolterodine.
What are the applications of Application
(2R,3R)-(+)-Bis(diphenylphosphino)butane is used for enantio-selective hydrogenations
Purification Methods
It recrystallises from absolute EtOH (~6g in 60mL) as colourless plates [Fryzuk & Bosnich J Am Chem Soc 99 6262 1977, Fryzuk & Bosnich J Am Chem Soc 101 3043 1979].
Properties of (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
| Melting point: | 104-109 °C |
| Boiling point: | 529.2±33.0 °C(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| color | white |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 74839-84-2 |
Safety information for (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 7-Bromo-1H-indazole N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid Electrolytic Iron Powder Fmoc-Val-Cit-PAB 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 1-(4-Methylphenylsulfonyl)-1H-1,2,3-benzotriazole 1-(2-Chlorobenzyl)-4-nitro-1H-pyrazole 1-(2-Nitrophenyl)-4-phenylpiperazineRelated products of tetrahydrofuran
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