(2R)-(-)-GLYCIDYL 4-NITROBENZOATE

Synonym(s):(R)-(−)-Glycidyl 4-nitrobenzoate;(R)-(−)-Oxirane-2-methanol 4-nitrobenzoate

CAS NO.：106268-95-5
Empirical Formula: C10H9NO5
Molecular Weight: 223.18
MDL number: MFCD00010835
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-21 16:56:50

(2R)-(-)-GLYCIDYL 4-NITROBENZOATE Structural

What is (2R)-(-)-GLYCIDYL 4-NITROBENZOATE?

The Uses of (2R)-(-)-GLYCIDYL 4-NITROBENZOATE

(2R)-(?)-Glycidyl 4-nitrobenzoate can be used as a starting material in the total synthesis of leukotriene B4.

Purification Methods

Purify glycidol by fractional distillation.The 4-nitrobenzoates have m 56o (±); m 60-62o, [] D20 -37.9o (c 3.38 CHCl3) for R-(-)-isomer [106268-95-5];m 60-62o, [] D20 +38o (c 1 CHCl3) for the S-(+)-isomer [115459-65-9] and are recrystallised from Et2O or Et2O/pet ether (b 40-60o) [S-isomer: Burgos et al. J Org Chem 52 4973 1987, Sowden & Fischer J Am Chem Soc 64 1291 1942.] [Beilstein 17 I 50, 17 III/IV 985, 17/3 V 9.]

Properties of (2R)-(-)-GLYCIDYL 4-NITROBENZOATE

Melting point:	60-62 °C (lit.)
storage temp.	2-8°C
optical activity	[α]19/D 37°, c = 1.08 in chloroform
BRN	5278590

Safety information for (2R)-(-)-GLYCIDYL 4-NITROBENZOATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.